NCT00004467

Who might be able to join this trial:

• You are between 18 and 70 years old
• You have been diagnosed with sudden (acute) liver failure, meaning your liver stopped working properly within the last 26 weeks and you have no history of long-term liver disease
• Your liver failure has caused changes in your mental awareness (such as confusion) and problems with blood clotting
• You are being treated in a hospital intensive care unit (ICU) and can start the study treatment within the first 24 hours of being admitted
• If you were already in the hospital for another reason and then developed confusion as a new symptom, you may also qualify
• If you were transferred from another hospital, you may still be eligible as long as no other specific treatment plan has been started and no special liver support machine has been used

Who may not be able to join:

• You are under 18 or over 70 years old
• Your liver failure is thought to be caused by a Tylenol (acetaminophen) overdose or mushroom poisoning
• Your liver failure was caused by a sudden loss of blood flow to the liver (sometimes called "shock liver"), though heat stroke is not automatically excluded
• You are pregnant, or your liver failure is related to pregnancy complications
• Your liver failure is thought to be caused by cancer spreading within the liver
• You are showing signs of severe brain swelling at the time of enrollment
• Your blood pressure is dangerously low (systolic at or below 70 mmHg) or you need medications to keep your blood pressure up at the time of enrollment
• You have a severe infection, including a very high fever (above 39°C / 102.2°F) or significant bacteria in the bloodstream at the time of enrollment

Important: Always verify eligibility with the trial site directly before applying.